Karey Kessler explores her internal landscape of time, place, and spirituality through the use of map imagery. Her work concerns issues about the environment, layers of geological history, the vastness of the universe, and the fleetingness of each moment.

Kessler's work is in the flat files of the Pierogi Gallery (New York City) and is included in two books: The Map as Art (Princeton Architectural Press, 2009), by Kitty Harmon and From Here to There: A Curious Collection From the Hand Drawn Map Association (Princeton Architectural Press, 2010). Her art was also published in the academic journal Imaginary Cartographies, English Language Notes (Issue 52.1, 2014) and most recently in Le Paysage est une traversée (Editions Parentheses, 2020).

Her work was included in Time Sensitive, at the Broto: Art-Climate-Science convention in 2020 (Provincetown, MA, online due to Covid-19) and the SciArt Initiative Bridge Residency in 2019. Kessler has shown her work widely, including exhibits at the Pennsylvania Academy of Fine Arts Museum (PA), the Weatherspoon Art Museum (NC), the Tacoma Art Museum (WA), Shift Gallery (WA), and most recently at the Bellevue Art Museum (WA).

From 2018-2020 Kessler had a temporary public art piece, A Path of Wonderment and Connection, along the new Rainier Valley Greenway in Seattle. Her vinyl street graphics are part of Art Interruptions 2018 which is funded by the Seattle Department of Transportation 1% for the arts and is administered by the Seattle Office of Arts and Culture. She currently has an installation on the Tacoma Tollbooth Gallery in Tacoma, WA.

Kessler is currently a member of Shift Gallery in Seattle and is a participant in an ongoing project, CoDraw Seattle.